Table 3 Pros and cons of different forms of necroinflammation.
From: Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Pros | Cons |
|---|---|
Cell death modalities differ in the mechanism of DAMP release | Each cell death process can be activated by multiple signaling pathways |
Different DAMPs are released during cell death modalities | Timely different DAMPs can be released in the same cell death pathway |
Critical DAMPS of the Th differentiation, such as IL-1, IL-33, SAMPs seems to be produced dominantly upon specific cell death forms. | Cell death pathways can work simultaneously |
Different posttranslational modifications of DAMPs are activated upon different cell death pathways | Cell death processes can be sequential events, activating each other. |
