Fig. 2: SNAIL levels are significantly upregulated with WNT5A overexpression and correlate with a poor prognosis. | Cell Death & Disease

Fig. 2: SNAIL levels are significantly upregulated with WNT5A overexpression and correlate with a poor prognosis.

From: WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway

Fig. 2: SNAIL levels are significantly upregulated with WNT5A overexpression and correlate with a poor prognosis.The alternative text for this image may have been generated using AI.

A Western blots showing WNT5A levels in various ESCC cells. B Representative western blots showing the levels of FLAG-WNT5A, SNAIL, E-cadherin, SLUG, TWIST1, and vimentin in WNT5A-overexpressing cells. β-actin was used as an internal control. C Representative IHC images showing SNAIL expression in ESCC tissues. Scale bars, 200 and 50 μm (inset). D Statistical analysis of SNAIL expression in 145 patients with ESCC based on the tissue microarray IHC results. E Kaplan–Meier survival analysis of 145 patients with ESCC presenting high/low SNAIL expression. F Correlation analysis of WNT5A and HDAC7 expression in ESCC tissues. G Comprehensive Kaplan–Meier survival analysis of 145 patients with ESCC presenting high/low WNT5A and SNAIL expression. LV lentivirus.

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