Fig. 5: The Cx43 hemichannel of TECs mediate ATP outflow and ATP receptor analysis. | Cell Death & Disease

Fig. 5: The Cx43 hemichannel of TECs mediate ATP outflow and ATP receptor analysis.

From: Blocking connexin 43 and its promotion of ATP release from renal tubular epithelial cells ameliorates renal fibrosis

Fig. 5: The Cx43 hemichannel of TECs mediate ATP outflow and ATP receptor analysis.

A, B Detection of intracellular ATP content in TECs. C scRNAseq identified clusters of cells in the Sham and UUO kidneys after surgery at day 7. UMAP plot representation of 30,788 kidney cells, including 20,590 cells from UUO kidney and 10,198 cells from Sham kidney. DotPlot (D, E), UMAP (F) and violin plots (G) depicted genes related to ATP receptor and pyroptosis. Data are presented as the mean ± SEM, n = 4–7/group, ***P < 0.001.

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