Fig. 3: ABR thresholds of SAMP8 mice before treatment and click-evoked ABR threshold shifts of SAMP8 mice treated with ACOU085 and vehicle control. | Cell Death & Disease

Fig. 3: ABR thresholds of SAMP8 mice before treatment and click-evoked ABR threshold shifts of SAMP8 mice treated with ACOU085 and vehicle control.

From: A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss

Fig. 3

a, b Mean and standard deviation of ABR thresholds are shown for SAMP8 mice at the age of 45 days before treatment with ACOU085 at 0.6% (a) or 6.0% (b) w/v dose or contralateral vehicle control. c, d Means (diamonds), box plots, and individual (circles) click-evoked auditory brainstem response (ABR) threshold shifts are shown for SAMP8 mice treated unilaterally with either 0.6% (c) or 6.0% (d) w/v ACOU085 and contralateral vehicle control measured at different timepoints: pre-treatment (preT), and 1-, 2-, 3-months post-treatment (postT). Threshold shifts were calculated as the difference between individual thresholds and the population mean at preT. Significant pairwise comparisons (paired-samples t-Test) are indicated by asterisks (*p < 0.05). Note that due to technical issues resulting in data loss, two mice had to be excluded at the 2-months and 1 mouse at the 3-months postT intervals, respectively, in the 6.0% group. This is denoted by “1e” and “2e”, i.e., 1 ear and 2 ears excluded, respectively.

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