Fig. 7: Proposed model of AK2 function as a BRAF locker in the RAS-BRAF signaling. | Cell Death & Disease

Fig. 7: Proposed model of AK2 function as a BRAF locker in the RAS-BRAF signaling.

From: AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis

Fig. 7: Proposed model of AK2 function as a BRAF locker in the RAS-BRAF signaling.The alt text for this image may have been generated using AI.

A Under resting condition with high AMP level, AK2 senses AMP and forms a protein complex with BRAF to inhibit the BRAF activity. B Upon mitogen stimulation and RAS activation, AK2 is released from BRAF, leading to activation of BRAF.

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