Fig. 5: Mitophagy induced by the inhibition of piR-823 potentiates apoptotic cell death in CRC cells. | Cell Death & Disease

Fig. 5: Mitophagy induced by the inhibition of piR-823 potentiates apoptotic cell death in CRC cells.

From: piR-823 inhibits cell apoptosis via modulating mitophagy by binding to PINK1 in colorectal cancer

Fig. 5: Mitophagy induced by the inhibition of piR-823 potentiates apoptotic cell death in CRC cells.

A TUNEL Apoptosis Assay was employed to analyze apoptosis. Scale bar: 10 μm. B Western blot analysis of cleaved PARP, cleaved-caspase-9 and cleaved-caspase-3. C Flow cytometric analysis of apoptosis in HCT116 and DLD-1 cells transtected with siNC or siParkin in combination with Ant-NC or Ant-823 for 72 h. Data are mean ± SD from at least three independent experiments, *P < 0.05, **P < 0.01, ***P < 0.001 vs control groups.

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