Fig. 3: NRF2 and the ferroptosis network.
From: Regulatory pathways and drugs associated with ferroptosis in tumors
a p62-mediated degradation of KEAP1 contributes to the activation of NRF2 in ferroptosis. The activated NRF2 enters the nucleus to initiate the transcription of antioxidant enzymes, glutathione redox system, iron metabolism, and other related molecules, alleviating oxidative stress, making tumor cells resistant to ferroptosis. b When NRF2 is degraded by ubiquitination, it cannot enter the nucleus to initiate the transcription of related genes. Second, ARE is a key regulator of NRF2-mediated SLC7A11 activation, and the ARE-NRF2 interaction is a p53-independent enhanced ferroptosis sensitivity approach.
