Fig. 7: Ripk2 over-expression alleviates intestinal damage caused by Card9 deficiency in sepsis. | Cell Death & Disease

Fig. 7: Ripk2 over-expression alleviates intestinal damage caused by Card9 deficiency in sepsis.

From: Card9 protects sepsis by regulating Ripk2-mediated activation of NLRP3 inflammasome in macrophages

Fig. 7

WT mice and Card9−/− mice (n = 10 for each group) were treated with LPS after 24 h Ad-Ripk2 injected into tail vein. A Secretion of IL-1β and IL-10 in serum was assessed by ELISA. B Production of AST and ALT was detected in serum. C Histological analysis of intestinal was shown by H&E staining. D Intestinal tissue from Card9−/− mice was staining with alcian blue. E Immumohistochemical analysis of ZO-1, Occludin and Claudin-2 in intestinal tissue from Card9−/− mice. Data are shown as mean ± SEM. Each group was representative of at least three biological replicates. **p < 0.01, ***p < 0.001.

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