Fig. 1: High Nkx2.8 expression associated with better prognosis in UC patients received chemotherapy.

A Survival analysis of 220 UC patients received chemotherapy from public database by different levels of Nkx2.8. B Negative or positive Nkx2.8 expression was relative to the recurrence of NMIBC. p values are indicated (chi-square test). C Negative or positive Nkx2.8 expression was relative to the progression of NMIBC. p values are indicated (chi-square test). D Comparison of the PFS of NMIBC patients with different levels of Nkx2.8 expression. p values are indicated (log-rank test). E Comparison of the RFS of NMIBC patients with different levels of Nkx2.8 expression. p values are indicated (log-rank test). F Percentage of MIBC specimens with or without recurrence relative to the negative or positive Nkx2.8 expression. p values are indicated (chi-square test). G Comparison of the OS of MIBC patients with different levels of Nkx2.8 expression. p values are indicated (log-rank test). H Comparison of the RFS of MIBC patients with different levels of Nkx2.8 expression. p values are indicated (log-rank test). I OS curves in MIBC patients in Nkx2.8 positive group who underwent radical cystectomy with or without adjuvant chemotherapy. p values are indicated (log-rank test). J OS curves in MIBC patients in Nkx2.8 negative group who underwent radical cystectomy with or without adjuvant chemotherapy. p values are indicated (log-rank test). K RFS curves in MIBC patients in Nkx2.8 positive group who underwent radical cystectomy with or without adjuvant chemotherapy. p values are indicated (log-rank test). L RFS curves in MIBC patients in Nkx2.8 negative group who underwent radical cystectomy with or without adjuvant chemotherapy. p values are indicated (log-rank test).