Fig. 2: FAT10 expression is correlated with chemoresistance of PC cells to GEM. | Cell Death & Disease

Fig. 2: FAT10 expression is correlated with chemoresistance of PC cells to GEM.

From: FAT10 promotes chemotherapeutic resistance in pancreatic cancer by inducing epithelial-mesenchymal transition via stabilization of FOXM1 expression

Fig. 2: FAT10 expression is correlated with chemoresistance of PC cells to GEM.

A Protein expression of FAT10 in noncancerous pancreatic ductal epithelial cells and PC cell lines was analyzed by western blotting. B The mRNA expression of FAT10 in normal pancreatic ductal epithelial cells and PC cell lines was analyzed by qRT–PCR. C Viabilities of PC cells were determined in response to different concentrations of GEM. Inhibition curves were fitted by nonlinear regression, and GEM IC50s were calculated using GraphPad Prism 8 software. D Western blotting was used to analyze expression levels of FAT10 in GEM-resistant (GR) PC cells. Data represent the mean ± SD of triplicate experiments and were statistically analyzed with Student’s t-test, *p < 0.05, **p < 0.01.

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