Fig. 7: C5aR1 inhibition blocks C5a- and paclitaxel-induced anaphylactoid cytokine release from mouse and human macrophages. | Cell Death & Disease

Fig. 7: C5aR1 inhibition blocks C5a- and paclitaxel-induced anaphylactoid cytokine release from mouse and human macrophages.

From: Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions

Fig. 7: C5aR1 inhibition blocks C5a- and paclitaxel-induced anaphylactoid cytokine release from mouse and human macrophages.

Proteome profiles of cytokines released from RAW 264.7 (A, B) and human (C, D) macrophages challenged with C5a (A, C) or paclitaxel (B, D) alone or in combination with a C5AR1 antibody (anti C5AR), Avacopan or DF3966A. RAW 264.7 and human macrophages cells were treated with C5a (10 nM), or paclitaxel (PAC) (10 nM), or DF3966A (1 μM) or Avacopan (1 μM) and C5aR1 antibody (1 μM) for 24 h. Data are mean ± SEM of n = 3 different experiments.

Back to article page