Fig. 1: High ARIH2 expression is correlated with poor GC patient prognosis. | Cell Death & Disease

Fig. 1: High ARIH2 expression is correlated with poor GC patient prognosis.

From: ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

Fig. 1

A Immunohistochemical staining analysis showed the expression of ARIH2 and quantified the expression of ARIH2 in normal and GC tumor tissues. Scale bar = 50 μm. B Box plot of ARIH2 expression levels in the peritumoral tissues (normal) and GC tumors with log-rank test P values < 0.05. C Western blot assays were used to detect the protein expression of ARIH2 in GC tissues and peritumoral tissues (normal), as well as in the normal gastric cell line (GES-1) and GC cell lines (BGC823, HGC27, MGC803, MKN45, SGC7901). D Kaplan–Meier analysis of progression-free survival using data from three different GC databases. All data are expressed as the mean ± SD. Student’s t test was performed to analyze significance. *P < 0.05, **P < 0.01, ***P < 0.001.

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