Fig. 6: GlcCer plays a crucial role in promoting the metastasis of liver cancer cells. | Cell Death & Disease

Fig. 6: GlcCer plays a crucial role in promoting the metastasis of liver cancer cells.

From: GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway

Fig. 6

A Diagram of cellular GlcCer metabolism. B, D The effect of PDMP or miglustat on the mechanism of inhibited migration and invasion of HepG2 cells with GBA1 knockdown, scale bar, 200 μm. C, E Western blotting was performed to determine the effect of PDMP or miglustat on GBA1 deficiency-upregulated proteins involved in the Wnt signalling pathway and EMT. F–I The relative number of migrated cells (F, H) and invaded cells (G, I) is shown.

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