Fig. 3: RNA profiling of A549 cells identifies differentially expressed gene sets after STX18 knockdown and irradiation. | Cell Death & Disease

Fig. 3: RNA profiling of A549 cells identifies differentially expressed gene sets after STX18 knockdown and irradiation.

From: Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer

Fig. 3

Differentially represented gene sets in shScr vs shSTX18 at basal level (a) and 24 h after irradiation with 10 Gy (b). Only the gene sets with an FDR < 0.25 are represented. For representation of A549-shSTX18 cells, counts from A549-shSTX18 K2 and K3 were pooled. c Enrichment plots of the gene sets “DNA repair”, “epithelial mesenchymal transition” and “TGFβ signaling” enriched in A549-shScr vs A549-shSTX18 K2 and K3. Biological replicates are indicated with I, II, and III. The 30 most enriched genes for each gene sets are represented. d Enrichment plots of the gene sets “mitotic spindle” and “G2/M checkpoint” enriched in A549-shScr vs A549-shSTX18 K2 and K3 after irradiation. Biological replicates are indicated with I, II, and III. The 30 most enriched genes for each gene sets are represented. n = 3.

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