Fig. 2: MEX3A knockdown inhibits the cell proliferation and tumor growth of ovarian cancer cells in vitro and in vivo. | Cell Death & Disease

Fig. 2: MEX3A knockdown inhibits the cell proliferation and tumor growth of ovarian cancer cells in vitro and in vivo.

From: MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS

Fig. 2: MEX3A knockdown inhibits the cell proliferation and tumor growth of ovarian cancer cells in vitro and in vivo.

A, B MEX3A knockdown and overexpression efficiency were confirmed by qRT-PCR (n = 4 biologically independent samples) and western blotting. C Growth curve showing the growth of ovarian cancer cells upon MEX3A knockdown or overexpression (n = 5 biologically independent samples). D EdU assay showed the proliferation ability changes of ovarian cancer cells after MEX3A knockdown (n = 5 biologically independent samples). E The clonogenic assay showed the clonogenic capacity changes of ovarian cancer cells after MEX3A knockdown and overexpression (n = 5 biologically independent samples). F Images of tumors isolated from subcutaneous implantation of nude mice with MEX3A knockdown and control cells (n = 6 mice per group). G Tumor size and weight statistics. P-value was obtained by unpaired t-test. Results represent the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01.

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