Fig. 8: Schematic of the function and mechanism of Ct-OATP1B3 in HGSOC metastasis. | Cell Death & Disease

Fig. 8: Schematic of the function and mechanism of Ct-OATP1B3 in HGSOC metastasis.

From: Ct-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation

Fig. 8: Schematic of the function and mechanism of Ct-OATP1B3 in HGSOC metastasis.The alternative text for this image may have been generated using AI.

Ct-OATP1B3 directly interacts with IGF2BP2 and increases the expression of CPT1A and NDUFA2, which enhances the FAO and OXPHOS activities and ATP production, thus leading to the lamellipodia formation and HGSOC cell migration and invasion.

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