Fig. 8: Ets-1/GPX2 axis regulates sorafenib resistance. | Cell Death & Disease

Fig. 8: Ets-1/GPX2 axis regulates sorafenib resistance.

From: Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma

Fig. 8

Hep3B-soraR cells were transfected with control-siRNA or two different GPX2-siRNA (#2, #4) and treated with DMSO or sorafenib for 48 h followed by flow cytometry to detect apoptosis (A), mitochondrial damage (B), or mROS (C). D Hep3B-soraR cells transfected and treated as in A were analyzed by western blots with the indicated antibodies. Cl PARP cleaved PARP, Cl Caspase 3 cleaved caspase 3.

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