Fig. 1: Inverse correlations between pPAK4 levels and α-synuclein aggregation in the substantia nigra of postmortem brain tissue from patients with PD. | Cell Death & Disease

Fig. 1: Inverse correlations between pPAK4 levels and α-synuclein aggregation in the substantia nigra of postmortem brain tissue from patients with PD.

From: p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1

Fig. 1: Inverse correlations between pPAK4 levels and α-synuclein aggregation in the substantia nigra of postmortem brain tissue from patients with PD.The alternative text for this image may have been generated using AI.

A Immunoblotting of SN lysates for pPAK4 and α-synuclein. B Quantification of the blot in A normalized to GAPDH. Age-matched controls and PD patients (n = 4 for each group). C Costaining for pPAK4 and pα-synS129. Scale bars, 25 µm. Boxed areas in C are shown at higher magnification. N neuromelanin. pPAK4, blue arrow; α-synuclein, red arrow. D Spearman correlation analysis for an inverse correlation between pPAK4 and pα-synS129 levels in human PD tissues. PD patients, n = 7; neuromelanin-positive cells, n = 63. r = −0.504, P < 0.05. E Model for the relationship between PAK4 activity and α-synuclein aggregation. The data are presented as the mean ± SEM. *P < 0.05. Unpaired Student’s t test (B) or two-way ANOVA (D) was used for statistical analysis followed by Tukey’s multiple comparisons test.

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