Fig. 2: Familial PMF with CHST15 mutation exhibits activation of immune/inflammation/extracellular matrix signals in PBMNCs. | Cell Death & Disease

Fig. 2: Familial PMF with CHST15 mutation exhibits activation of immune/inflammation/extracellular matrix signals in PBMNCs.

From: CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk

Fig. 2: Familial PMF with CHST15 mutation exhibits activation of immune/inflammation/extracellular matrix signals in PBMNCs.

A Heatmap shows hierarchical clustering of expression profiles of 4 differentially expressed CHST15 target genes in familial PMF (red:upregulation;blue:downregulation). Microarray assay of genes with >2.0-fold upregulation or downregulation. B Familial essential thrombocythemia (ET) genes expression profiles. Heatmap shows hierarchical clustering of profiles of 12 differentially expressed genes. C Genes expression profiles both in familial PMF and in familial ET.

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