Fig. 1: PCB2 protects against lung I/R injury in mice. | Cell Death & Disease

Fig. 1: PCB2 protects against lung I/R injury in mice.

From: Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury

Fig. 1: PCB2 protects against lung I/R injury in mice.The alternative text for this image may have been generated using AI.

a–f C57BL/6 mice were subjected to 1 h of ischemia followed by 2 h of reperfusion to establish lung I/R injury; mice from the control group underwent sham surgical procedures. The indicated dosages of PCB2 were injected intraperitoneally for three consecutive days before the operation. a Representative images of the H&E-stained lung tissue. Scale bar = 200 μm. Black arrows indicate representative pathological damage. b Histopathological scores (Mikawa’s score) of the lung, n = 6. The dosage of PCB2 was 15 or 30 mg/kg, as indicated. c The survival rate of the mice, n = 15. The dosage of PCB2 was 30 mg/kg. d–f The W/D ratio, total protein concentration in BALF and MPO activity in the lung, n = 6. The dosage of PCB2 was 15 or 30 mg/kg, as indicated. *p < 0.05. Error bars depict the standard deviations.

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