Fig. 7: Exosome-mediated delivery of circWDR62 induces TMZ resistance and malignant progression of glioma cells in vitro. | Cell Death & Disease

Fig. 7: Exosome-mediated delivery of circWDR62 induces TMZ resistance and malignant progression of glioma cells in vitro.

From: Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma

Fig. 7

A Exosomes from TMZ-resistant glioma cells were labelled with PKH67 and then cocultured with TMZ-sensitive glioma cells. B PKH67-labelled TMZ-resistant glioma cell-derived exosomes were endocytosed by TMZ-sensitive glioma cells. C The expression levels of circWDR62 in TMZ-sensitive glioma cells were measured by qRT–PCR after treatment with TMZ-resistant glioma cell-derived exosomes. D The effects of the EV secretion inhibitor GW4689 on circWDR62 transport from U343-R and U251-R cells to U343 and U251 recipient cells. E The EdU assay was performed to assess the proliferation ability of TMZ-sensitive glioma cells after treatment with TMZ-resistant glioma cell-derived exosomes. F, G Transwell assays were performed to assess the cell invasion (F) and migration (G) of TMZ-sensitive glioma cells after treatment with TMZ-resistant glioma cell-derived exosomes.

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