Fig. 8: Schematic illustration.
From: LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease
Uremic toxin in the serum derived from CKD patients induce overexpression of ANRIL, and ANRIL mediate brain-derived neurotrophic factor (BDNF) promoter methylation through recruitment of EZH2 to the BDNF promoter region, eventually resulting in endothelial dysfunction.
