Fig. 6: PPP6C loss alleviates TNF-induced necroptosis in SIRS model.
From: Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1
A Representative H&E staining of cecum from Ppp6cf/+ and ShhCre/+;Ppp6cf/+ mice (n = 3 each group at a time point) injected with TNF for the indicated time. Scale bar, 100 μm. B Cecal proteins from Ppp6cf/+ and ShhCre/+;Ppp6cf/+ mice injected with TNF for 8 h were analyzed by immunoblot with indicated antibodies. C A schematic model shows that PPP6C positively regulates TNF-induced necroptosis via TAK1-IKKα/β axis.
