Fig. 7: Genome alterations in cancer patient specimens with altered CHEK2 and JAK2. | Cell Death & Disease

Fig. 7: Genome alterations in cancer patient specimens with altered CHEK2 and JAK2.

From: JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability

Fig. 7

A Deletion of JAK2 is associated with increased genome alterations. Datasets were analyzed using the cBioportal for Cancer Genomics platform (https://www.cbioportal.org). n = 10939. B–D Copy number alterations of genes in relation to mutations and copy number alteration of CHEK2 and JAK2. The gene alteration frequency in groups with altered CHEK2 and JAK2 vs. unaltered groups was compared and shown in scatter plot (B) and volcano plots (C). Genes with the highest frequency were selected and compared between the two groups in (D). Datasets from seven pan-cancer studies were analyzed. Altered group, n = 703. Unaltered group, n = 37045. E, F Higher expression of CHEK2 and JAK2 correlates with better survival among patients with lung squamous cell carcinoma (E) and breast cancer (F), respectively. Overall survival among patients was analyzed using Kaplan–Meier Plotter (http://kmplot.com/analysis) with pan-cancer RNA-seq datasets. Shown are the results from the analysis of lung squamous cell carcinoma (n = 501) and breast cancer (n = 1090) for the expression of CHEK2 (E) and JAK2 (F), respectively. G Summary of the JAK2-CHK2-Mps1 signaling axis in the regulation of spindle checkpoint.

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