Fig. 6: MiR-155-5p promotes mesenchymal transition by targeting ACOT12. | Cell Death & Disease

Fig. 6: MiR-155-5p promotes mesenchymal transition by targeting ACOT12.

From: Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12

Fig. 6

A, B Relative expression levels of mesenchymal transition-related markers (TWIST2, vimentin and N-cadherin) in glioma cells transfected with si-ACOT12 determined by RT-qPCR and western blotting; C, D Relative mRNA and protein levels of mesenchymal transition-related markers in glioma cells transfected with miR-155-5p inhibitor alone or co-transfected with si-ACOT12 and miR-155-5p inhibitor; E Schematic diagram of the hypothetical mechanism of the GSCs-derived exosomal miR-155-5p enhances aggressiveness by targeting ACOT12 and promoting mesenchymal transition in glioma. Data represent as the mean ± SEM (repetition = 3). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (Student’s t-test).

Back to article page