Fig. 6: Sestrin2 reverses podocyte phenotypic alterations along with reduction in podocyte number of diabetic mice. | Cell Death & Disease

Fig. 6: Sestrin2 reverses podocyte phenotypic alterations along with reduction in podocyte number of diabetic mice.

From: Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease

Fig. 6: Sestrin2 reverses podocyte phenotypic alterations along with reduction in podocyte number of diabetic mice.The alternative text for this image may have been generated using AI.

A–D The expression of nephrin, synaptopodin and WT-1 of glomeruli from WT, WT + DM, TgN and TgN+DM mice were detected by immunohistochemistry (For nephrin and synaptopodin, 10 glomeruli were analyzed; and for WT-1, 20 glomeruli were analyzed. n = 5). E–J A representative Western blot and relevant quantification of α-SMA, E-cadherin, desmin, nephrin and synaptopodin in glomeruli from mice of four different groups (n = 3). WT wild-type mice, WT + DM diabetic WT mice, TgN B6-TgN (CMV-Sestrin2) mice, TgN+DM diabetic TgN mice, WT-1 Wilms’ Tumor 1. Data are expressed as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page