Fig. 7: Sestrin2 reverts increased expression of apoptosis-associated proteins in podocytes of diabetic mice. | Cell Death & Disease

Fig. 7: Sestrin2 reverts increased expression of apoptosis-associated proteins in podocytes of diabetic mice.

From: Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease

Fig. 7

A–D A representative Western blot and relevant quantification of Bax, Bcl-2, and Cleaved Caspase-3 in glomeruli from mice of WT, WT + DM, TgN and TgN+DM groups (n = 3). E Representative immunofluorescence images of Bax (green) and synaptopodin (red) in glomeruli from four groups of mice, and DAPI is a dye for nucleus. WT wild-type mice, WT + DM diabetic WT mice; TgN: B6-TgN (CMV-Sestrin2) mice; TgN + DM diabetic TgN mice. Data are expressed as mean ± SD. **P < 0.01, ***P < 0.001.

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