Fig. 1: The research scheme and RRA analysis of DEGs in ALI. | Cell Death & Disease

Fig. 1: The research scheme and RRA analysis of DEGs in ALI.

From: Caveolin-1 identified as a key mediator of acute lung injury using bioinformatics and functional research

Fig. 1: The research scheme and RRA analysis of DEGs in ALI.The alternative text for this image may have been generated using AI.

A Research scheme and a flow framework. We analyzed 5 ALI datasets using bioinformatics, screened out common differential genes, and performed GO, KEGG, and PPI analysis on these differential genes. The mRNA and protein expressions of the CAV-1 and RELA were verified in vitro and in vivo. The functions of CAV-1 and RELA were further verified to explore the potential mechanism in ALI. B Heatmap demonstrated the 40 robust DEGs between the ALI and control. Twenty genes were promoted and twenty genes were suppressed in ALI. Red shows upregulated gene expression and green shows downregulated gene expression in ALI. Numbers in the heatmap indicate log2 FC of genes in the five datasets compared with control groups. C The log2 FC of 40 DEGs was calculated from five datasets. The log2 FC sums of CAV-1 and RELA were 0.99 and 0.63, suggesting these two genes were significantly upregulated in ALI.

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