Fig. 8: Molecular mechanism of CAV-1-mediated LPS-induced ALI development. | Cell Death & Disease

Fig. 8: Molecular mechanism of CAV-1-mediated LPS-induced ALI development.

From: Caveolin-1 identified as a key mediator of acute lung injury using bioinformatics and functional research

Fig. 8

CAV-1 expression is upregulated in LPS-induced ALI, which recruits CD3+ T lymphocytes and F4/80+ macrophages to lung tissue, thereby triggering inflammatory response. Meanwhile, upregulated CAV-1 could promote AKT/mTOR and inhibit AMPK to downregulate autophagy, resulting in ALI. Conversely, knockdown of CAV-1 ameliorates ALI.

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