Fig. 6: The inhibitory effect of NXN on HCC cells proliferation and metastasis was rescued by the overexpression of Snail. | Cell Death & Disease

Fig. 6: The inhibitory effect of NXN on HCC cells proliferation and metastasis was rescued by the overexpression of Snail.

From: NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3

Fig. 6

Overexpression of Snail attenuated NXN induced suppression of HCC cell growth, evaluated by CCK8 (A) and colony formation assays (B). Overexpression of Snail attenuated NXN induced suppression of HCC cell migration, evaluated by Transwell (C) and wound healing assay (D). Depletion of Snail in NXN knockdown group reversed NXN deficiency-induced promotion of HCC metastasis in nude mice. E Representative images and quantification of metastatic lung tumors (gross and HE staining after tail vein injection. Scale bar, 100 µm. Five mice per group. Statistical results were presented as mean ± SD (from triplicates), and significance was determined by Student’s t-test (*P < 0.05).

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