Fig. 3: Loss of FOXA1 promoted autophagic cell death in LUAD cells under metabolic stress conditions. | Cell Death & Disease

Fig. 3: Loss of FOXA1 promoted autophagic cell death in LUAD cells under metabolic stress conditions.

From: FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma

Fig. 3: Loss of FOXA1 promoted autophagic cell death in LUAD cells under metabolic stress conditions.

A Colony formation assays were used to evaluate cell survival in FOXA1-depleted or FOXA1-silenced PC-9 cells upon treatment with specific cell death inhibitors. CQ (10 μM), 3-MA (2 mM), Z-VAD (20 μM), Nec-1 (20 μM), Fer-1 (10 μM). Mean ± SD, n = 3. B The protein levels of autophagy-related genes were determined by western blot. C Colony formation assays were used to evaluate cell survival in FOXA1-depleted or FOXA1-silenced PC-9 cells upon inhibition of autophagy-related genes. Mean ± SD, n = 3. *P < 0.05; **P < 0.01; ***P < 0.001, NS not significant.

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