Fig. 7: FOXA1 expression reduced the efficacy of nintedanib against xenograft tumors derived from A549 cells.

A Growth curve of xenograft tumors in nude mice. Mean ± SD, n = 10. B Macro view of xenograft tumors. C Weights of xenograft tumors as measured at the endpoint of the experiment. Mean ± SD, n = 10. D H&E staining and immunohistochemistry staining of xenograft tumors. Ni nintedanib (100 mg/kg). li linsitinib (25 mg/kg). ra rapamycin (4 mg/kg).