Fig. 1: PTPN18 interacts with MVP in vitro and in vivo.
From: Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2
A Proteins identified in the immunopurified PTPN18 complexes by mass spectrometry. B Summary of functional similarities of the PTPN18 interactome in MCF7 cells. C The physical association between endogenous PTPN18 and MVP was validated using immunoprecipitation (IP) in MCF7 and T-47D cells. D Co-IP showed the interaction between ectopic PTPN18 and MVP in 293 T cells. E GST pull-down assay with GST-tagged PTPN18 and His-tagged MVP. F Representative immunofluorescence images showing the colocalization of PTPN18 (green) and MVP (red) in MCF7 cells.
