Fig. 6: Nuclear PTPN18 inhibits lung metastasis in mouse model.
From: Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2
A Normalized bioluminescence signals of lung metastases in mice injected intravenously with MDA-MB-231 cells with overexpressing PTPN18 WT or cytoplasmic PTPN18. **P < 0.01. B Representative bioluminescence image of mice in each experimental group at the indicated time points. C Representative bioluminescence image of lung metastatic nodules. D Normalized bioluminescence signals in lung metastatic nodules from mice. ***P < 0.001; ****P < 0.0001. E Quantification of lung metastatic nodules from mice. ***P < 0.001; ****P < 0.0001.
