Fig. 2: The expression of CD36 and NLRP3 inflammasome was upregulated in MRL/lpr mice with renal impairment. | Cell Death & Disease

Fig. 2: The expression of CD36 and NLRP3 inflammasome was upregulated in MRL/lpr mice with renal impairment.

From: CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis

Fig. 2: The expression of CD36 and NLRP3 inflammasome was upregulated in MRL/lpr mice with renal impairment.

A The urinary protein levels of C57 BL/6 and MRL/lpr mice were shown by urinary Albumin/Creatinine (uACR) (20w C57 BL /6 vs. 20w MRL/lpr). B Renal tissue sections were stained with HE, PAS, Masson, PASM-Masson to assess renal pathology (scale bar 20 μm) (original magnification: ×400). C–F Immunohistochemical staining showed the localization and relative quantification of CD36, NLRP3 protein in murine kidney (C57 BL/6 and MRL/lpr mice; scale bar 20 μm and 5 μm). The relative expression of protein was indirectly reflected by AOD value. The red arrow denoted the most prominent podocyte (original magnification: ×400). G Quantitative expression of CD36, NLRP3, Caspase1, Cleaved-Caspase1, IL-1β, Nephrin, Podocin, protein in renal tissue homogenate from C57 BL/6 and MRL/lpr mice was detected by western blot analysis (8w MRL/lpr vs. 20w MRL/lpr; 20w C57 BL/6 vs. 20w MRL/lpr). Cle-Caspase1: Cleaved-Caspase1. Data are expressed as the mean ± SD. *p < 0.05. **p < 0.01. ***p < 0.001.

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