Fig. 6: Nintedanib induces a senolytic effect in senescent HDFs via JAK2/STAT3 pathway.
From: Nintedanib induces senolytic effect via STAT3 inhibition

Proposed mechanism of senolytic effect induced by nintedanib. Nintedanib-induced senescent cell death is mediated by inhibiting STAT3 activity. Additionally, nintedanib causes cell cycle arrest in nonsenescent cells by regulating CDK2.