Fig. 7: FOXD1 expression correlates with GLUT1 in PC.

A Representative image of FOXD1, HOXA11-AS, miR-148b-3p, and GLUT1 expression in serial sections of pancreatic cancer specimens detected through IHC and ISH. Pearson’s chi-squared test of the expression of 40 specimens. B GLUT1 expression of MIA PaCa-2 and PANC-1 cells with FOXD1 overexpression and knock-down were detected using western blotting. C Illustration of how FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis, created by Figdraw (http://www.figdraw.com). *p < 0.05; **p < 0.01.