Fig. 7: FBXO22 promotes HCC cell growth and survival by silencing p57Kip2 expression.
From: Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation
A The protein levels of FBXO22 and p57Kip2 were detected by Western blotting in SiHa and C33A control (shCtr) and FBXO22 knockdown (shR2) cells transfected with a control siRNA (CtrsiRNA) or a p57Kip2 siRNA (p57siRNA). B, C MTT (B) and colony formation (C) assays were used to measure the viability and proliferation in SiHa and C33A cells with or without FBXO22 and/or p57 knockdown. D, E Cell cycle was analyzed in SiHa and C33A cells with or without FBXO22 and/or p57 knockdown. F Cell apoptosis was analyzed in SiHa and C33A cells with or without FBXO22 and/or p57 knockdown. Data are shown as mean ± SEM from triplicate measurements. *P < 0.05, **P < 0.01, ***P < 0.001.
