Fig. 1: HOX genes expression patterns and clinical significance of HOXD11 in PSCC. | Cell Death & Disease

Fig. 1: HOX genes expression patterns and clinical significance of HOXD11 in PSCC.

From: miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma

Fig. 1: HOX genes expression patterns and clinical significance of HOXD11 in PSCC.

Total mRNA was extracted from 12 pN+ PSCC patients with corresponding N, PCA and LM tissues. A The HOX genes mRNA expression profile of 12 paired tissues. B Among the 34 HOX genes, the mRNA expression of HOXB2, HOXD10 and HOXD11 in tumors especially in LM were striking increased. C For each PSCC patients, HOXD11 was overexpressed step by step in PCA and LM than normal tissues. D The HOXD11 proteins was increased in tumor tissues and PSCC cell lines. E The IHC assays indicated the expression of HOXD11 in paired tissues in a pT3N3M1 PSCC patients. F The mRNA levels of HOXD11 were upregulated in 93 tumor tissues compared with those in 21 normal tissues. Overexpression of HOXD11 was associated with poor pT, pN stages and ENE. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. NS not significant, N normal squamous epithelium, PCA primary carcinoma, LM metastatic lymph node, HaCaT human immortalized keratinocytes, IHC immunohistochemistry, ENE extranodal extension, PSCC penile squamous cell carcinoma.

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