Fig. 6: HOXD11 induced the degradation of extracellular matrix via the FN1/MMP2/MMP9 pathways. | Cell Death & Disease

Fig. 6: HOXD11 induced the degradation of extracellular matrix via the FN1/MMP2/MMP9 pathways.

From: miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma

Fig. 6

A The mRNA expression of FN1 in 24 PSCC tumors and 8 normal tissues. B The expression relationship of target genes in 24 PSCC patients by Pearson correlation analysis. C The expression pattern of FN1 in PSCC tumors by IHC assays. D High FN1 expression was associated with poor survival in PSCC. E, F Western bolt and immunocytochemistry showed the decreased protein expression of FN1, MMP2 and MMP9 when knockdown of HOXD11 in PSCC cells. G, H Immunofluorescence indicated that overexpression of HOXD11 in 149rca cells increased the expression of FN1, MMP2 and MMP9. While the expression of MMP2 and MMP9 were inhibited by siRNA-FN1transfection. I, J Knockdown of FN1 inhibited cell invasion in PSCC, and undermined the progressive potential of cell invasion in HOXD11 overexpression cells. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Statistics are presented as the means ± SDs of three independent experiments.

Back to article page