Fig. 7: miR-138-5p repressed HOXD11 expression and inhibited cell invasion in PSCC. | Cell Death & Disease

Fig. 7: miR-138-5p repressed HOXD11 expression and inhibited cell invasion in PSCC.

From: miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma

Fig. 7: miR-138-5p repressed HOXD11 expression and inhibited cell invasion in PSCC.

A The flow chart of target miRNA screening. B, C The expression of miR-138-5p was down-regulated in PSCC tumors and was associated with better survival. D TargetScan predicted the bounding sites between miR-138-5p and HOXD11 3′UTR. E Luciferase reporter assays indicated that miR-138-5p directly bound with the region of HOXD11 3′UTR. F, G Cell invasion activity was significantly inhibited in miR-138-5p mimics transfectants, and promoted in miR-138-5p inhibitors transfectants comparing with miR-control transfectant cells. H, I The invasive cells were reversed when transfecting with miR-138-5p mimics in HOXD11 overexpression 149rca cells.

Back to article page