Table 1 Clinicopathological characteristics and the association with HOXD11 expression in 267 PSCC patients.

From: miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma

Variable

PSCC cohort (N = 267), %

HOXD11 IHC staining

χ2

p-valuea

Low expression (N = 182), %

High expression (N = 85), %

Age

   

0.019

0.890

 <55

143 (53.6)

98 (36.7)

45 (16.9)

  

 ≥55

124 (46.4)

84 (31.5)

40 (15.0)

  

pT status

   

13.720

0.003b

 ≤pT1c

102 (38.2)

78 (29.2)

24 (9.0)

  

 pT2

49 (18.4)

30 (11.2)

19 (7.1)

  

 pT3

104 (39.0)

71 (26.6)

33 (12.4)

  

 pT4

12 (4.5)

3 (1.1)

9 (3.4)

  

pN status

   

38.695

0.000

 N0

141 (52.8)

118 (44.2)

23 (8.6)

  

 N1

32 (12.0)

21 (7.9)

11 (4.1)

  

 N2

30 (11.2)

16 (6.0)

14 (5.2)

  

 N3

64 (24.0)

27 (10.1)

37 (13.9)

  

Metastasis

   

18.650

0.000b

 M0

248 (92.9)

178 (66.7)

70 (26.2)

  

 M1

19 (7.1)

4 (1.5)

15 (5.6)

  

Clinical stage

   

33.743

0.000

 Stage I

70 (26.2)

58 (21.7)

12 (4.5)

  

 Stage II

70 (26.2)

57 (21.3)

13 (4.9)

  

 Stage III

55 (20.6)

36 (13.5)

19 (7.1)

  

 Stage IV

72 (27.0)

31 (11.6)

41 (15.4)

  

Histology

   

9.006

0.011

 G1

129 (48.3)

99 (37.1)

30 (11.2)

  

 G2

95 (35.6)

59 (22.1)

36 (13.5)

  

 G3

43 (16.1)

24 (9.0)

19 (7.1)

  

ENE

   

23.887

0.000

 No

218 (81.6)

163 (61.0)

55 (20.6)

  

 Yes

49 (18.4)

19 (7.1)

30 (11.2)

  

PLNMd

   

4.298

0.038

 No

23 (62.2)

20 (54.1)

3 (8.1)

  

 Yes

14 (37.8)

7 (18.9)

7 (18.9)

  
  1. aChi-square test; bFisher’s exact test; cIncluded Ta, Tis and pT1 patients; dA total of 37 PSCC patients underwent pelvic lymph node dissection. ENE extranodal extension, PLNM Pelvic lymph node metastasis, PSCC penile squamous cell carcinoma.
  2. Bold values indicates that the results were statistically significant.
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