Fig. 4: SFXN2 modulates bioenergetic processes via accelerating cellular iron utilization and aggravates tumor burden in MM xenograft model. | Cell Death & Disease

Fig. 4: SFXN2 modulates bioenergetic processes via accelerating cellular iron utilization and aggravates tumor burden in MM xenograft model.

From: Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Fig. 4: SFXN2 modulates bioenergetic processes via accelerating cellular iron utilization and aggravates tumor burden in MM xenograft model.The alternative text for this image may have been generated using AI.

a The cellular iron contents of WT, SFXN2-OE, SFXN2-Ctrl, and SFXN2-KD cells were examined by using Prussian blue iron staining. b Quantification of Prussian blue iron staining. c Flow cytometry analysis of ferrous ion content indicated by Calcein-AM fluorescence intensity. d The iron content was significantly higher in SFXN2-OE cells than WT cells while the iron content in SFXN2-KD cells was lower than control cells. e The images of the xenograft mice and xenografts taken from the mice. f The analysis of tumor volume. g The analysis of tumor weight.

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