Fig. 1: Rb1 protects ECs from ox-LDL/HG-induced cell viability decline and oxidative stress. | Cell Death & Disease

Fig. 1: Rb1 protects ECs from ox-LDL/HG-induced cell viability decline and oxidative stress.

From: A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

Fig. 1

EA.hy926 ECs were pretreated with Rb1 (3, 10, and 30 μM) for 30 min before ox-LDL/HG for 24 h. A Cell viability measured by CCK-8 assay. B MDA contents. C Quantitative analysis of DHE staining. D Representative images of DHE staining. Scale bar = 200 μm. E Cell cycle was determined by flow cytometer and the cell cycle distribution was calculated. F EdU incorporation experiments and EdU-positive cells were quantified. Scale bar = 200 μm. Data are presented as mean ± SEM. n = 4–6. Statistical analysis was performed with the randomized block ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001; vs. indicated group.

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