Fig. 8: Nrf2 and PGC-1α are required for Rb1 to ameliorate diabetes-accelerated atherosclerosis in mice. | Cell Death & Disease

Fig. 8: Nrf2 and PGC-1α are required for Rb1 to ameliorate diabetes-accelerated atherosclerosis in mice.

From: A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

Fig. 8: Nrf2 and PGC-1α are required for Rb1 to ameliorate diabetes-accelerated atherosclerosis in mice.The alternative text for this image may have been generated using AI.

A Schema showing the experimental procedure in mice. B, H Lesion areas indicated by Oil O Red staining of the thoracoabdominal aorta. C, D Representative blots and quantitative analysis of Nrf2 and PGC-1α in primary mouse ECs. E, I H&E staining and quantification of aortic root sections. Scale bar = 100 μm. F Oil O Red staining of aortic root sections. Scale bar = 100 μm. G, J DHE staining of thoracic aorta. Scale bar = 50 μm. K Relative mRNA levels of VCAM-1, IL-1β, IL-6, and TNF-α. Data are presented as mean ± SEM. n = 4–6. Statistical analysis was performed with the randomized block ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001; vs. indicated group.

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