Fig. 7: p66Shc overexpression exacerbates USP15 knockdown-ameliorated apoptosis, inflammation, and oxidative stress in liver I/R. | Cell Death & Disease

Fig. 7: p66Shc overexpression exacerbates USP15 knockdown-ameliorated apoptosis, inflammation, and oxidative stress in liver I/R.

From: USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion

Fig. 7

A–D AAV-TBG-p66Shc and AAV-TBG-USP15 shRNA were successively injected to mice followed by liver I/R. A Serum ALT, AST and LDH levels, n = 8. B Liver IL-1β, IL-6 and TNF-α mRNA levels, n = 6. C Liver SOD, CAT, H2O2, and MDA contents, n = 8. D USP15, p66Shc, Bcl2, Bax, and C-cas-3 protein expression. E pcDNA-p66Shc and USP15 siRNA were co-transfected to AML12 cells followed by H/R. USP15, p66Shc, Bcl2, Bax and C-cas-3 protein expression, n = 3. #P < 0.05, ##P < 0.01.

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