Fig. 7: RSV rescues CRI in vivo by regulating AMPK/SIRT7/HMGB1 axis. | Cell Death & Disease

Fig. 7: RSV rescues CRI in vivo by regulating AMPK/SIRT7/HMGB1 axis.

From: Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

Fig. 7

IHC detection of SIRT7 (a) and HMGB1 (b) in the cutaneous tissues from mice posterior limb treated with solvent or 20 μM RSV and exposed to 40 Gy radiation. Scale bar: 50 μm. c Schematic illustration showing the time course for topical cutaneous application of RSV and IR exposure to subcutaneous xenografts. d Imaging of subcutaneous xenografts as control or treated with IR plus solvent or IR plus RSV on day 0 and day 8. e Tumor volumes (mm3) were recorded every 2 days. Tumor volume statistical data represent the average of independent experiments ± s.d., respectively. *p < 0.05, **p < 0.01, ***p < 0.001. f A model depicts the AMPK/SIRT7/HMGB1 regulatory axis that mediates the protective function of RSV to alleviate CRI.

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