Fig. 4: Roxadustat suppressed chemoresistant GBM growth in vivo and prolonged survival of the GBM mice. | Cell Death & Disease

Fig. 4: Roxadustat suppressed chemoresistant GBM growth in vivo and prolonged survival of the GBM mice.

From: HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis

Fig. 4: Roxadustat suppressed chemoresistant GBM growth in vivo and prolonged survival of the GBM mice.The alternative text for this image may have been generated using AI.

A IVIS images and associated ROI quantification of orthotopic GBM-bearing mice injected with RXD (10 mg/kg) and/or TMZ (35 mg/kg), measured every 7 days (0–21 days). *P < 0.05, **P < 0.01. B The body weight of mice in each group after drug injection was monitored and recorded every 3 days (0–21 days). C The survival curves of orthotopic GBM-bearing mice (n = 5). *P < 0.05, **P < 0.01.

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