Fig. 3: The mechanism of crosstalk interactions between CAFs and tumor cells.
From: The role of cancer-associated fibroblasts in tumorigenesis of gastric cancer
The mechanisms by which tumor cells interact with CAFs remain to be elucidated. CAFs and tumor cells may cooperate to invade via diverse communication behaviors, including the chemoattractant gradient produced by soluble cytokines, different secretory patterns, which including paracrine and autocrine signaling, exosomes, and direct communication.
