Fig. 3: CAFs support metabolic reprogramming of tumour cells.
From: Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
CAFs help malignant cells overcome nutrient deprivation. Under the influence of tumour cells, CAFs perform aerobic glycolysis and provide nutrients to PDAC cells. Moreover, CAFs-derived collagens and HA in the ECM can also be used by tumour cells. Also, CAFs contribute to the metabolism reprogramming of malignant cells. The exosomes released by CAFs can also fuel the metabolism in PDAC cells. Furthermore, CAFs engage in autophagy to generate energy-rich metabolites that serve as alternative carbon sources for mitochondrial metabolism and tumour growth.
